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Hematopoietic stem cells (HSC) can expand and replace hematopoietic cells in the bone marrow, allowing recovery from blood system injury or infection. LPS is a potent stimulator of myelopoiesis. In this study, HSC colony formation assays were used to quantify the effects of LPS exposure on the frequency and absolute number of HSC in the bone marrow of mice. LPS exposure significantly increased the frequency of HSC in the bone marrow by about 2-fold compared with unexposed mice. The absolute number of HSC in the bone marrow of LPS-exposed mice was also higher than that of unexposed mice. This result suggests that LPS exposure has the potential to mobilize HSC and that the bone marrow of LPS-exposed mice may be repopulated earlier than that of unexposed mice. Therefore, HSC exposed to LPS may be more important in the regeneration of the blood system than those unexposed to LPS.You are here
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